In vivo antidiarrheal activity of aqueous and ethanolic leaves extracts of Rumex bequaertii De Wild (Polygonaceae) in experimental induce diarrhea in Wistar Albino rats

Purpose: The present study aimed at investigating the antidiarrheal activity of the aqueous and ethanolic extracts of Rumex bequaertii leaves in animal models.
Methods: Phytochemical screening was performed using different standard methods. Different doses of the aqueous and ethanolic extracts of Rumex bequaertii (EERb) leaves (120, 240 and 480 mg/kg) were tested for antidiarrheal activity using Castor oil, magnesium sulphate induced diarrhea and misoprostol induced fluid accumulation in Wistar rats.
Results: The phytochemical study carried out showed the presence of tannins, flavonoids, triterpenoids, alkaloids, anthraquinones and phenols. Extracts activities at different doses were compared with negative control groups. Administration of the extract at all tested doses resulted in the reduction of the number of wet feces, frequency of defecation, mass of feces and fluid accumulation. Conclusion: Aqueous and ethanolic leaves extracts of Rumex bequaertii possess antidiarrheal activity. These results bring a scientific validation to the traditional use of Rumex bequaertii for the treatment of diarrhea.