Secondary metabolites from an endophytic fungus Trichoderma erinaceum (IT-58) with antimicrobial activity towards Pythium ultimum

B. boat.b, D. W. Kamtchaa,, O. Youassib, S. Zamste K. G. Bedanec*, S. G. Tchamenib*,
aUniversity of Dschang,
bUniversity of Douala
cUniversity of Ethiopia,

Abstract
Chemical investigation of the endophytic fungus, Trichoderma erinaceum, isolated from common bean field crop showing the typical symptoms of root disease, resulted in the isolation of a new alkene, (Z)-5-amino-5-(1,1,2-trihydroxybuta-1,3-dienyloxy)pentane-6,7,8,9-tetraol (1), together with five known compounds (2–6). The structures of the compounds were elucidated by analysis of their spectroscopic data including 1D, 2D NMR, ESI–HRMS and literature data. The organic crude extract and the compound isolated from T. erinaceum moderately inhibited the mycelial growth of Pythium ultimum.

Keywords: Antimicrobial activity, endophytic fungus, Pythium ultimum, Trichoderma erinaceum,